NEUR-898 Doctoral Continuing Enrollment
NEUR-899 Doctoral Dissertation
BIO-210 General Biology II
BIO-210 General Biology II
BIO-487 Principles of Genomics
CORE-105 Complex Problems Seminar: Obesity: a Complex Crisis
Paffhausen E*, Alowais Y*, Chao C, Callihan E, Creswell K, Bracht, JR. Discovery of a stem-like multipotent cell fate. American Journal of Stem Cells. In press. (* = co-first authors)
Lindblad KA*, Bracht, JR*, Williams AE, Landweber LF. Thousands of RNA-cached copies of whole chromosomes are present in the ciliate Oxytricha during development. RNA. 2017 April 27. (* co-first authors)
Bracht JR*, Wang X*, Shetty K, Chen X, Uttarotai G, Callihan E, McCloud S, Clay D, Wang J, Nowacki M, Landweber LF. Chromosome fusions triggered by noncoding RNA. RNA Biology. 2016 Jun 7:1-12. (* co-first authors)
Chen X*, Bracht JR*, Goldman A, Swart E, Dolzhenko E, Swart E, Clay D, Perlman DH, Doak TG, Stuart A, Amemiya C, Landweber LF. The architecture of a scrambled genome reveals massive levels of genomic rearrangement during development. Cell, Aug. 28, 2014. (*co-first authors)
Bracht JR. Beyond transcriptional silencing: Is cytosine methylation a widely conserved eukaryotic DNA elimination mechanism? BioEssays. April 2014 36(4):346-52.
Bracht JR, Fang W, Goldman AD, Dolzhenko E, Stein EM, Landweber LF. Genomes on the Edge: Programmed Genome Instability in Ciliates. Cell. 2013 Jan 31;152(3):406-416.
Swart E, Bracht JR, Magrini V, Minx P,Chen X, Zhou Y, Khurana J, Goldman AD, Nowacki M, Schotanus K, et al. The Oxytricha trifallax Macronuclear Genome: A Complex Eukaryotic Genome with over 16,000 Tiny Chromosomes. PLoS Biology. 2013 Jan 29;11(1).
Fang W, Wang X, Bracht JR, Nowacki M, Landweber LF. Piwi-Interacting RNAs Protect DNA Against Loss During Oxytricha Genome Rearrangement. Cell. 2012 Dec 7;151(6):1243-1255.
Bracht JR*, Perlman DH, Landweber LF*. Cytosine methylation and hydroxymethylation mark DNA for elimination in Oxytricha trifallax. Genome Biology. 2012 Oct 17;13(10):R99. *corresponding.
The Bracht lab investigates the process of genome rearrangement in the ciliate Oxytricha trifallax: Genomic methods used in this work include next-generation sequencing of DNA and RNA, cell culture, and computational methods.
Honors, Awards, and Fellowships
NSF I-Corps Teams. Using genomics to detect pathogens. National Science Foundation. (2016-2017)
K22 Transition Career Development Award (National Institutes of Health, National Cancer Institute): Model systems for the investigation of DNA methylation and drug repurposing (2014-2017)
F32 NRSA Postoctoral Fellowship: Epigenetic regulation of programmed genome instability in O. trifallax (2012-2014)
Area of Expertise
cell biology, genomics, computational genomics
Bracht researches how genome architecture is established and maintained in healthy cells and how it goes awry in disease. He uses a unicellular eukaryote, the ciliate Oxytricha trifallax, as a model system for the role of epigenetics — information on the DNA molecule but outside the DNA sequence — in controlling genome architecture.